Vaginal estrogen treatment does not increase the threat of death in clients with breast cancer, according to research study released in JAMA Oncology
In truth, scientists discovered modest reductions in the threat of breast cancer-specific death and all-cause death amongst clients who utilized vaginal estrogen treatment.
In this population-based research study, scientists analyzed information from nationwide cancer computer registries in Scotland and Wales for 49,237 ladies detected with breast cancer in between the ages of 40 and 79 years.
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After breast cancer medical diagnosis, 5% of clients utilized vaginal estrogen treatment, and 1% got systemic hormonal agent replacement treatment (HRT).
There were 5795 breast cancer-specific deaths at a mean follow-up of 5 years in the Scotland associate and 8 years in the Wales associate.
In an adjusted analysis, there was a modest reduction in the threat of breast cancer-specific death amongst clients who utilized vaginal estrogen treatment (danger ratio [HR], 0.77; 95% CI, 0.63-0.94; P =.01).
Outcomes were comparable whether clients got 1-4 vaginal estrogen treatment prescriptions (HR, 0.81; 95% CI, 0.67-0.99; P =.04) or 5 or more prescriptions (HR, 0.57; 95% CI, 0.34-0.96; P =.03).
There was no substantial association with lower-dose vaginal estrogen treatment (HR, 0.77; 95% CI, 0.56-1.07; P =.12) or higher-dose treatment (HR, 0.81; 95% CI, 0.55-1.21; P =.31).
The scientists likewise discovered no substantial association in between systemic HRT usage and breast cancer-specific death (HR, 0.98; 95% CI, 0.68-1.40; P =.90).
Similarly, there was no substantial association in between vaginal estrogen usage and cardiovascular death (aHR, 0.78; 95% CI, 0.28-2.16), however there was a modest reduction in the threat of all-cause death amongst vaginal estrogen users (aHR, 0.80; 95% CI, 0.71-0.90).
These findings “might offer some peace of mind to recommending clinicians and support the standards recommending that vaginal estrogen treatment can be thought about in clients with breast cancer and genitourinary signs if nonhormonal treatments are not successful,” the scientists concluded.
Disclosures: Among the research study authors stated associations with biotech, pharmaceutical, and/or gadget business. Please see the initial referral for a complete list of disclosures.
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McVicker L, Labeit AM, Coupland CAC, et al. Vaginal estrogen treatment usage and survival in women with breast cancer JAMA Oncol. Released online November 2, 2023. doi:10.1001/ jamaoncol.2023.4508
This post initially appeared on Cancer Treatment Consultant